The most common and most likely answer to this crossword clue is the 8 letter word BLEAKEST
I've seen this crossword clue in The Times
B
L
E
A
K
E
S
T
More clues leading to the result BLEAKEST
Buddy explains!
The straight part
We know that "most depressing" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case most depressing = bleakest.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does BLEAKEST mean?
BLEAKEST adjective- Without color; pale; pallid.
- Desolate and exposed; swept by cold winds.
- Unhappy; cheerless; miserable; emotionally desolate.