Cryptic crossword clue
100 is 2’s to gain – with crown to lose out 7

The most common and most likely answer to this crossword clue is the 7 letter word ANTILOG

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Buddy explains!

The straight part
We know that "100 is 2’s" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case 100 is 2’s = antilog.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ANTILOG mean?

ANTILOG noun
  1. An antilogarithm.

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