Cryptic crossword clue
16D Rue Simon is an address in Quebec 8

The most common and most likely answer to this crossword clue is the 8 letter word MONSIEUR

I've seen this crossword clue in Independent
M
O
N
S
I
E
U
R

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MONSIEUR mean?

MONSIEUR noun
  1. A man, especially a French gentleman.

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