Cryptic crossword clue
18d

The most common and most likely answer to this crossword clue is the 7 letter word DRASTIC

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "Very harsh wine downed by doctor with cold (7)/Very harsh" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case very harsh wine downed by doctor with cold (7)/very harsh = drastic.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DRASTIC mean?

DRASTIC noun
  1. A powerful, fast-acting purgative medicine.
DRASTIC adjective
  1. Having a strong or far-reaching effect; extreme, severe.
  2. Acting rapidly or violently.

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