Cryptic crossword clue
& 18d    Take off production with a C-list despicable duo 4,1,5,4,2,5

The most common and most likely answer to this crossword clue is the 4 plus 1 plus 5 plus 4 plus 2 plus 5 letter word SHOW A CLEAN PAIR OF HEELS

I've seen this crossword clue in The Daily Telegraph
S
H
O
W
A
C
L
E
A
N
P
A
I
R
O
F
H
E
E
L
S

Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

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