Cryptic crossword clue
19 Southwestern enterprise zone vacated in allergic response 6

The most common and most likely answer to this crossword clue is the 6 letter word SNEEZE

I've seen this crossword clue in The Guardian
S
N
E
E
Z
E


Buddy explains!

The straight part
We know that "allergic response/allergic response/allergic response" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case allergic response/allergic response/allergic response = sneeze.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SNEEZE mean?

SNEEZE noun
  1. An act of sneezing.
SNEEZE verb
  1. To expel air as a reflex induced by an irritation in the nose.
  2. To expel air as if the nose were irritated.

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