Cryptic crossword clue
/21 Shark malaria affecting 3 in America 6,6

The most common and most likely answer to this crossword clue is the 6 plus 6 letter word KAMALA HARRIS

I've seen this crossword clue in Independent
K
A
M
A
L
A
H
A
R
R
I
S

Buddy explains!

The straight part
We know that "3 in America" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case 3 in america = kamala harris.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

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