Cryptic crossword clue
22 Gangster follows extremely confidential working of a genetic copy 6

The most common and most likely answer to this crossword clue is the 6 letter word CLONAL

C
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Buddy explains!

The straight part
We know that "of a genetic copy" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case of a genetic copy = clonal.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CLONAL mean?

CLONAL adjective
  1. Relating to, or created by asexual reproduction (cloning)
  2. That lives with others of the same kind

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