Cryptic crossword clue
26 That's gone into supplement regularly — it helped 5

The most common and most likely answer to this crossword clue is the 5 letter word AIDED

A
I
D
E
D

Buddy explains!

The straight part
We know that "helped" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case helped = aided.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does AIDED mean?

AIDED verb
  1. To provide support to; to further the progress of; to help; to assist.
  2. To climb with the use of aids such as pitons.

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