Cryptic crossword clue
4 across’s 4 across, perhaps, 4 across to leave skin infection 8

The most common and most likely answer to this crossword clue is the 8 letter word IMPETIGO

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "skin infection" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case skin infection = impetigo.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does IMPETIGO mean?

IMPETIGO noun
  1. A contagious bacterial skin disease forming pustules and yellow crusty sores, chiefly on the face and hands. It is common in children and infection is often through cuts or insect bites.

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