Cryptic crossword clue
45 royalist nuts devoted to 20s 10

The most common and most likely answer to this crossword clue is the 10 letter word EPISTOLARY

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "devoted to 20s" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case devoted to 20s = epistolary.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EPISTOLARY mean?

EPISTOLARY noun
  1. A Christian liturgical book containing set readings for church services from the New Testament Epistles.
EPISTOLARY adjective
  1. Of or relating to letters, or the writing of letters.
  2. Carried on by written correspondence.
  3. In the manner of written correspondence.

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