The most common and most likely answer to this crossword clue is the 6 letter word DRUPEL
I've seen this crossword clue in Independent
D
R
U
P
E
L
Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does DRUPEL mean?
DRUPEL noun- One of the small drupe-like subdivisions which compose the outer layer of certain fruit such as blackberries or raspberries.