The most common and most likely answer to this crossword clue is the 6 letter word ALIGHT
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Buddy explains!
The straight part
We know that "Come off it" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case come off it = alight.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ALIGHT mean?
ALIGHT verb- (with from) To get off or exit a vehicle or animal; to descend; to dismount.
- (with on or at) To descend and settle, lodge, rest, or stop.
- (followed by upon) To find by accident; to come upon.
- To befall or betide.
- To make light or less heavy; lighten; alleviate.
- To light; light up; illuminate.
- To set light to; light.
- Lit, on fire, switched on.
- Lit; on fire, burning.