Cryptic crossword clue
A bottle with contents switched is to be of use 5

The most common and most likely answer to this crossword clue is the 5 letter word AVAIL

I've seen this crossword clue in The Times
A
V
A
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The straight part
We know that "use" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case use = avail.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does AVAIL mean?

AVAIL noun
  1. Effect in achieving a goal or aim; purpose, use (now usually in negative constructions).
  2. Proceeds; profits from business transactions.
  3. An advertising slot or package.
  4. A press avail.
  5. Non-binding notice of availability for work.
  6. A readily available stock of oil.
  7. Benefit; value, profit; advantage toward success.
  8. Effort; striving.
AVAIL verb
  1. To turn to the advantage of.
  2. To be of service to.
  3. To promote; to assist.
  4. To be of use or advantage; to answer or serve the purpose; to have strength, force, or efficacy sufficient to accomplish the object.
  5. To provide; to make available.

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