Cryptic crossword clue
A cardinal caught in bishop’s office having meeting with 4 6

The most common and most likely answer to this crossword clue is the 6 letter word SEANCE

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "meeting with 4" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case meeting with 4 = seance.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SEANCE mean?

SEANCE noun
  1. A ceremony where people try to communicate with the spirits of dead people, usually led by a medium.
  2. The sitting of an assembly to discuss a matter.
SEANCE verb
  1. To hold a séance (communication with spirits).

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