Cryptic crossword clue
A Charlie being employed endlessly gives you the pip! 6

The most common and most likely answer to this crossword clue is the 6 letter word ACINUS

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Buddy explains!

The straight part
We know that "the pip!" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case the pip! = acinus.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ACINUS mean?

ACINUS noun
  1. One of the small grains or drupelets which make up some kinds of fruit, as the blackberry, raspberry, etc.
  2. A grape-stone.
  3. One of the granular masses which constitute a racemose or compound gland, as the pancreas; also, one of the saccular recesses in the lobules of a racemose gland.

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