Cryptic crossword clue
A comfort in it? I must be mistaken 13

The most common and most likely answer to this crossword clue is the 13 letter word MORTIFICATION

I've seen this crossword clue in The Times
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The straight part
We know that "A comfort in it? I must be mistaken" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case a comfort in it? i must be mistaken = mortification.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

Crossword Answer definitions

MORTIFICATION noun
  1. The act of mortifying.
  2. A sensation of extreme shame or embarrassment.
  3. The death of part of the body.
  4. A bringing under of the passions and appetites by a severe or strict manner of living.
  5. A bequest to a charitable institution.

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