The most common and most likely answer to this crossword clue is the 5 letter word ARMED
I've seen this crossword clue in The Daily Telegraph
A
R
M
E
D
More clues leading to the result ARMED
- Prepared to be hurt if husband leaves
- Cockney injured carrying a gun?
- Hospital leaving injured protected?
- Ready for engagement? What Mr and Mrs share is embodied by mostly expensive rings coming up
- Husband leaves injured, carrying weapon
- Marine brought into A&E died with weapon
- Hekmatyar mediates to provide with weapon
- Injured? Not hard with a sword, maybe
- Having certain members injured
- Equipped in cardiovascular medicine
Buddy explains!

The straight part
We know that "with weapons" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case with weapons = armed.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ARMED mean?
ARMED verb- To take by the arm; to take up in one's arms.
- To supply with armour or (later especially) weapons.
- To prepare a tool or a weapon for action; to activate.
- To cover or furnish with a plate, or with whatever will add strength, force, security, or efficiency.
- To furnish with means of defence; to prepare for resistance; to fortify, in a moral sense.
- To take up weapons; to arm oneself.
- To fit (a magnet) with an armature.
- (sometimes in combination) Equipped, especially with a weapon.
- (of a weapon) Prepared for use; loaded.
- Furnished with whatever serves to add strength, force, or efficiency.
- Having prickles or thorns.
- (chiefly in combination) Having an arm or arms, often of a specified number or type.
- (of a creature) Possessing arms of a specified number or type.
- (heraldry, of animals) Having horns, claws, teeth, a beak, etc. in a particular tincture, as contrasted with that of the animal as a whole.