The most common and most likely answer to this crossword clue is the 6 letter word AGOUTI
I've seen this crossword clue in The Guardian
A
G
O
U
T
I
More clues leading to the result AGOUTI
- A painful swelling produced by one rodent
- Rodent disease contained by artificial intelligence
- A painful condition oppresses one rodent
- For all to see in uncovered wagon, note rodent
- Rodent in the open an American soldier traps
- Rodent disease detected in a child’s stomach
- A condition causing swelling on one rodent
- Answer American soldier bagging forbidden source of bushmeat
- A taste one’s acquired for rodent
- Rodent disease found in sloth
Buddy explains!

The straight part
We know that "rodent" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case rodent = agouti.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does AGOUTI mean?
AGOUTI noun- A rodent similar in appearance to a guinea pig but having longer legs, of the family Dasyprocta.
- A fur containing a pattern of pigmentation in which individual hairs have several bands of light and dark pigment with black tips; any of several genes responsible for this pigmentation.