Cryptic crossword clue
A couple of fellows drunk caught in distress greatly 7

The most common and most likely answer to this crossword clue is the 7 letter word AFFLICT

A
F
F
L
I
C
T


Buddy explains!

The straight part
We know that "distress greatly" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case distress greatly = afflict.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does AFFLICT mean?

AFFLICT verb
  1. To cause (someone) pain, suffering or distress.
  2. To strike or cast down; to overthrow.
  3. To make low or humble.

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