Cryptic crossword clue
A crack up leaves one not right in the head 4

The most common and most likely answer to this crossword clue is the 4 letter word GAGA

G
A
G
A

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The straight part
We know that "not right in the head" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case not right in the head = gaga.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GAGA mean?

GAGA adjective
  1. Mentally senile.
  2. Crazy.
  3. Infatuated.
GAGA noun
  1. A variant of dodgeball played inside a fenced area, usually a hexagon or octagon.

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