Cryptic crossword clue
A cross can’t be played with — it’s very holy 10

The most common and most likely answer to this crossword clue is the 10 letter word SACROSANCT

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "very holy" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case very holy = sacrosanct.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SACROSANCT mean?

SACROSANCT adjective
  1. Beyond alteration, criticism, or interference, especially due to religious sanction; inviolable.
  2. Sacred, very holy.

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