Cryptic crossword clue
A distraught sob by musician who dislikes Fifty Shades of Grey? 10

The most common and most likely answer to this crossword clue is the 10 letter word ABSOLUTIST

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "who dislikes Fifty Shades of Grey?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case who dislikes fifty shades of grey? = absolutist.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

Crossword Answer definitions

ABSOLUTIST noun
  1. One who is in favor of an absolute or autocratic government.
  2. One who believes that it is possible to realize a cognition or concept of the Absolute.
  3. An uncompromising person; one who maintains certain principles to be absolute.
ABSOLUTIST adjective
  1. Of or pertaining to absolutism; arbitrary; despotic; uncompromising.

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