The most common and most likely answer to this crossword clue is the 7 letter word INNARDS
I've seen this crossword clue in The Times
I
N
N
A
R
D
S
More clues leading to the result INNARDS
- A doctor backed probing boozer’s guts
- Works in pub with odd people out of clubs
- One’s gutted to lose these pubs, cut through by a road
- Finding a way to break into pubs shows guts
- Guts sardine, after cutting off tail, to stew with end of lemon
- Faulty drains blocked by new entrails
- Bits inside pub somewhere in NI
- Guts shown by local while crossing road
- What gutter removes when crossing road behind pub
- Sin, pervertedly groping excited short randy organs
Buddy explains!

The straight part
We know that "guts" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case guts = innards.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does INNARDS mean?
INNARDS noun- Entrail; gut; intestine.
- The internal organs of a human or animal; especially viscera, intestines.
- The inner workings of something; the insides or guts.