The most common and most likely answer to this crossword clue is the 5 letter word UNTIE
U
N
T
I
E
More clues leading to the result UNTIE
- Family member doesn't start to let loose
- BBC releasing article for free
- BBC missing a release?
- Free time in university — Edinburgh, principally
- United Nations sports fixture for free
- Community and detention centres contest release
- A French match is separate
- Loosen link, it's back to front
- Account, I expect, not entirely free
- Free article given away by relative
Buddy explains!

The straight part
We know that "separate" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case separate = untie.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does UNTIE mean?
UNTIE verb- To loosen, as something interlaced or knotted; to disengage the parts of.
- To free from fastening or from restraint; to let loose; to unbind.
- To resolve; to unfold; to clear.
- To become untied or loosed.
- In the Perl programming language, to undo the process of tying, so that a variable uses default instead of custom functionality.