Cryptic crossword clue
A hat is seen ruining American number 10

The most common and most likely answer to this crossword clue is the 10 letter word ANESTHESIA

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The straight part
We know that "American number" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case american number = anesthesia.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ANESTHESIA mean?

ANESTHESIA noun
  1. An artificial method of preventing sensation, used to eliminate pain without causing loss of vital functions, by the administration of one or more agents which block pain impulses before transmitted to the brain.
  2. The loss or prevention of sensation, as caused by anesthesia, lesion in the nervous system or other physical abnormality.

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