The most common and most likely answer to this crossword clue is the 6 letter word AMULET
I've seen this crossword clue in The Times
A
M
U
L
E
T
More clues leading to the result AMULET
- Charm a Greek character hired out
- Charm of a stubborn person taking time
- Charm in a hybrid tree, originally
- Mate excitedly clutches extremely useful trinket
- A hybrid tea said to be a talisman
- Cross at hosts for displaying charm
- Engaged in protecting cross, one combats evil
- Charm left out of a hairdo
- A drug-smuggler on time? This may be lucky
- Charm, a cross, first of three
Buddy explains!

The straight part
We know that "talisman" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case talisman = amulet.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does AMULET mean?
AMULET noun- A kind of protective charm or ornament, often bearing magical symbols, worn for protection against ill will, negative influences or evil spirits.