Cryptic crossword clue
A large cat and mice somehow adapt  9

The most common and most likely answer to this crossword clue is the 9 letter word ACCLIMATE

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Buddy explains!

The straight part
We know that "adapt" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case adapt = acclimate.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ACCLIMATE mean?

ACCLIMATE verb
  1. To habituate to a climate not native; to acclimatize.
  2. To adjust to a new environment; not necessarily a wild, natural, earthy one.
  3. To become accustomed to a new climate or environment.

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