The most common and most likely answer to this crossword clue is the 4 letter word MANY
I've seen this crossword clue in The Guardian
M
A
N
Y
More clues leading to the result MANY
- A lot that’s new in a month in spring
- Numerous staff close to embassy
- Scores piece, finale from Debussy
- “Brexit-seeking Remainer” describes unspecified number a lot
- We ultimately embody what ‘ye’ are in 25’s 4 22
- Lots married one
- Article kept in writer’s stacks
- A large number — doesn’t matter which large number
- Large number — doesn’t matter which, a large number
- Masses held by German youths
Buddy explains!

The straight part
We know that "large number" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case large number = many.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MANY mean?
MANY noun- A multitude; a great aggregate; a mass of people; the generality; the common herd.
- A considerable number.
- A large number of; numerous.
- An indefinite large number of people or things.