Cryptic crossword clue
A large number try returning small design 6

The most common and most likely answer to this crossword clue is the 6 letter word GOOGOL

I've seen this crossword clue in Independent
G
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Buddy explains!

The straight part
We know that "A large number" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case a large number = googol.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GOOGOL mean?

GOOGOL numeral
  1. The number 10^{100}, or ten to the power of a hundred.

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