Cryptic crossword clue
A little radioactive matter in contact with the molecular constituents of water: whoops! 2-2

The most common and most likely answer to this crossword clue is the 5 letter word UH-OH

U
H
-
O
H

Buddy explains!

The straight part
We know that "whoops!" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case whoops! = uh-oh.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does UH-OH mean?

UH-OH interjection
  1. An exclamation of error, concern, or awareness of a problem.

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