Cryptic crossword clue
A lot of moonshine filling most of neighbouring astronomical object 6

The most common and most likely answer to this crossword clue is the 6 letter word NEBULA

N
E
B
U
L
A

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The straight part
We know that "astronomical object" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case astronomical object = nebula.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NEBULA mean?

NEBULA noun
  1. A cloud in outer space consisting of gas or dust (e.g. a cloud formed after a star explodes).
  2. A white spot or slight opacity of the cornea.
  3. A cloudy appearance in the urine

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