Cryptic crossword clue
A maiden disheartened with input/output in state of pregnancy 5

The most common and most likely answer to this crossword clue is the 5 letter word AMNIO

A
M
N
I
O

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The straight part
We know that "state of pregnancy" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case state of pregnancy = amnio.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does AMNIO mean?

AMNIO noun
  1. Amniocentesis

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