The most common and most likely answer to this crossword clue is the 3 letter word NEO
I've seen this crossword clue in The Guardian
N
E
O
More clues leading to the result NEO
- Reform I saw in modern evolutionary theory
- Modified one’s language
- I refuse to accept base words from Arturo Alfandari
- Erroneously includes a character in The Matrix
- The Artificial Tongue of Eugene Onegin
- Racist extremists restrained by Liberal in one
- Prefix for -conservative or -lithic
- A new prefix, one I prepared earlier?
Buddy explains!
The straight part
We know that "A new prefix" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case a new prefix = neo.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does NEO mean?
NEO noun- A newcomer to science fiction; a fan who is extremely new and inexperienced with the genre; a beginner.