The most common and most likely answer to this crossword clue is the 7 letter word ORGANON
O
R
G
A
N
O
N
More clues leading to the result ORGANON
- Method of investigation will require domain name soon
- System of rules abused in Rangoon
- Brain perhaps working -- there's logic to this
- System of rules broken in Rangoon
- Implanted in Cyborg, a no-nonsense set of principles
- Keeping an eye, say on a set of principles in philosophy
- Newspaper's operative set of principles
- A newspaper takes on a system of rules
Buddy explains!

The straight part
We know that "system of rules" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case system of rules = organon.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ORGANON mean?
ORGANON noun- A set of principles that are used in science or philosophy.
- The name given by Aristotle's followers to his six works on logic.