Cryptic crossword clue
A Parisian female upset and embarrassed must be toughened up 6

The most common and most likely answer to this crossword clue is the 6 letter word ENURED

E
N
U
R
E
D

Buddy explains!

The straight part
We know that "toughened up" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case toughened up = enured.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ENURED mean?

ENURED verb
  1. To inure; to make accustomed or desensitized to something unpleasant due to constant exposure.
  2. To take effect, to be operative; used with to.

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