The most common and most likely answer to this crossword clue is the 5 letter word VODKA
I've seen this crossword clue in The Times
V
O
D
K
A
More clues leading to the result VODKA
- A peacemaker cut up about vitamin shot?
- Old duke regularly seen in V&A shows spirit
- What leads to kulak vomiting all over dacha when drunk?
- Heads of vineyard outlets don’t keep any spirit
- Dvorak composed with outright spirit
- 5 + 0 + 500 + 1000 + 1 has strong proof?
- Dvorak’s fourth missing composition shows spirit
- It’s still produced in Russia
- Drink drop of kirsch at party back in Virginia
- Dave almost OK drunk — with this?
Buddy explains!

The straight part
We know that "shot" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case shot = vodka.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does VODKA mean?
VODKA noun- A clear distilled alcoholic liquor made from grain mash.
- A serving of the above beverage.
- Neutral spirits distilled (or treated after distillation) so as to have no distinctive character, aroma, taste or color.