The most common and most likely answer to this crossword clue is the 10 letter word PRECAUTION
I've seen this crossword clue in The Guardian
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More clues leading to the result PRECAUTION
Buddy explains!

The straight part
We know that "safety measure" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case safety measure = precaution.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does PRECAUTION mean?
PRECAUTION noun- Previous caution or care; caution previously employed to prevent misfortune or to secure good
- A measure taken beforehand to ward off evil or secure good or success; a precautionary act.
- To warn or caution beforehand.
- To take precaution against.