Cryptic crossword clue
A plea for help to tackle leading cause of cancer 8

The most common and most likely answer to this crossword clue is the 8 letter word ASBESTOS

I've seen this crossword clue in The Times
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Buddy explains!

The straight part
We know that "cause of cancer" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case cause of cancer = asbestos.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ASBESTOS mean?

ASBESTOS noun
  1. Any of several fibrous mineral forms of magnesium silicate, used for fireproofing, electrical insulation, building materials, brake linings, chemical filters, suits, fireman's gloves, etc.
  2. Any of asbestos-like forms of several minerals, asbestiforms

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