The most common and most likely answer to this crossword clue is the 5 plus 3 letter word INERT GAS
I've seen this crossword clue in The Daily Telegraph
I
N
E
R
T
G
A
S
More clues leading to the result INERT GAS
- He perhaps gets spattered with rain
- One never reacting to foul ingrates
- Angriest exchange when argon was called this?
- He is one running Tangiers
- He perhaps isn’t seething with rage
- He maybe is great shakes around Nigeria’s capital
- He perhaps has run away from arresting criminal
- It’s argon? Neon? Neither taking on being reactive
- A resting drunk, one won’t react
- One doesn’t react, being troubled by 7
Buddy explains!
The straight part
We know that "one won’t react" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one won’t react = inert gas.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.