The most common and most likely answer to this crossword clue is the 12 letter word REORIENTATED
I've seen this crossword clue in The Times
R
E
O
R
I
E
N
T
A
T
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D
Buddy explains!
The straight part
We know that "set out in a new direction" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case set out in a new direction = reorientated.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does REORIENTATED mean?
REORIENTATED verb- To orientate anew; to cause to face a different direction.