Cryptic crossword clue
A root infested badly? It leads to many a tree being destroyed 13

The most common and most likely answer to this crossword clue is the 13 letter word DEFORESTATION

I've seen this crossword clue in The Daily Telegraph
D
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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does DEFORESTATION mean?

DEFORESTATION noun
  1. The process of destroying a forest and replacing it with something else, especially with an agricultural system.
  2. A transformation to eliminate intermediate data structures within a program.

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