Cryptic crossword clue
A second, so great in itself 2,4

The most common and most likely answer to this crossword clue is the 2 plus 4 letter word AS SUCH

I've seen this crossword clue in The Daily Telegraph
A
S
S
U
C
H


Buddy explains!

The straight part
We know that "in itself" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case in itself = as such.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.


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