The most common and most likely answer to this crossword clue is the 10 letter word PENICILLIN
I've seen this crossword clue in The Guardian
P
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N
I
C
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L
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N
More clues leading to the result PENICILLIN
- Drawing, not good, featuring current pioneering drug
- Writing mostly about one’s antibiotic
- Antibiotic fix covering nurse in charge getting sick
- Enter tentatively; one left, entering separately for medical course?
- A shot writer nurses one left at home
- State founder holds French here, confining infected — in need of this?
- Drug one found in drawer, none turned up
- Drug — writer takes one, not finishing bit of script
Buddy explains!
The straight part
We know that "A shot" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case a shot = penicillin.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does PENICILLIN mean?
PENICILLIN noun- Any of a group of narrow-spectrum antibiotics obtained from Penicillium molds or synthesized; they have a beta-lactam structure; most are active against gram-positive bacteria and used in the treatment of various infections and diseases.