Cryptic crossword clue
A small animal circled a larger animal with some dexterity and irritated 8

The most common and most likely answer to this crossword clue is the 8 letter word HARASSED

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Buddy explains!

The straight part
We know that "irritated" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case irritated = harassed.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HARASSED mean?

HARASSED verb
  1. To fatigue or to tire with repeated and exhausting efforts.
  2. To annoy endlessly or systematically; to molest.
  3. To put excessive burdens upon; to subject to anxieties.

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