The most common and most likely answer to this crossword clue is the 7 letter word APACHES
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Buddy explains!
The straight part
We know that "Indians in America" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case indians in america = apaches.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does APACHES mean?
APACHES noun- Any of several Athabascan-speaking peoples of the American southwest excluding Navajo, i.e. Chiricahua, Jicarilla, Lipan, Mescalero, Plains Apache, or Western Apache.
- A person belonging to an Apache people.
- A Parisian gangster of the late 19th and early 20th centuries.
- AH-64 Apache, a U.S. military helicopter.