The most common and most likely answer to this crossword clue is the 7 letter word MALAISE
M
A
L
A
I
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E
More clues leading to the result MALAISE
- Depressed feeling SE Asians talked of
- First sign of anxiety is seen in fellow, bringing discomfort
- A term for fall in local amount of herring causing despondency
- From Guatemala, I sense a general problem
- One blocking fake e-mails causes discomfort
- Part of Guatemala is experiencing disease
- Supply a smile, hiding one’s discomfort
- Discomfort from a meal is dreadful
- Tom, perhaps, keeping sloths in discomfort
- Analgesia lamentably concealed mounting depression
Buddy explains!

The straight part
We know that "despondency" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case despondency = malaise.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MALAISE mean?
MALAISE noun- A feeling of general bodily discomfort, fatigue or unpleasantness, often at the onset of illness.
- An ambiguous feeling of mental or moral depression.
- Ill will or hurtful feelings for others or someone.