The most common and most likely answer to this crossword clue is the 10 letter word ABSCONDING
I've seen this crossword clue in The Times
A
B
S
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More clues leading to the result ABSCONDING
Buddy explains!
The straight part
We know that "taking off" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case taking off = absconding.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ABSCONDING mean?
ABSCONDING verb- To flee, often secretly; to steal away, particularly to avoid arrest or prosecution.
- To withdraw from.
- To evade, to hide or flee from.
- To conceal; to take away.
- To hide, to be in hiding or concealment.
- An instance in which someone absconds.