Cryptic crossword clue
A villain finally turning up on the fifth dimension’s fourth hub 4

The most common and most likely answer to this crossword clue is the 4 letter word NAVE

I've seen this crossword clue in The Guardian
N
A
V
E


Buddy explains!

The straight part
We know that "hub" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case hub = nave.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NAVE mean?

NAVE noun
  1. The middle or body of a church, extending from the transepts to the principal entrances.
NAVE noun
  1. A hub of a wheel.
  2. The navel.

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