The most common and most likely answer to this crossword clue is the 8 letter word PFEIFFER
I've seen this crossword clue in Financial Times
P
F
E
I
F
F
E
R
Buddy explains!
The straight part
We know that "A Witch of Eastwick" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case a witch of eastwick = pfeiffer.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.